A new biochemistry connecting pathogen detection to induced defense in plants

Summary Plant cell surface and intracellular immune receptors recognizing pathogen attack utilize the same defense machineries to mobilize resistance. New genetic, protein structural and biochemical information on receptor activation and signaling is transforming understanding of how their shared de...

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Bibliographic Details
Published in:	The New phytologist Vol. 234; no. 3; pp. 819 - 826
Main Authors:	Parker, Jane E., Hessler, Giuliana, Cui, Haitao
Format:	Journal Article
Language:	English
Published:	England Wiley Subscription Services, Inc 01-05-2022
Subjects:	Arabidopsis - genetics Arabidopsis Proteins - metabolism Biochemistry Calcium ions Calcium signalling Cell surface Connecting Dimers Disease resistance EDS1 effector‐triggered immunity immune receptor Immunity Interleukins Intracellular Leucine NAD NADase NLR Proteins - metabolism Nucleotides Pathogens pattern‐triggered immunity Plant Diseases Plant Immunity - genetics Plants - metabolism Proteins Receptor mechanisms Receptors RNL Signaling TIR RNL pattern-triggered immunity disease resistance immune receptor NADase TIR EDS1 effector-triggered immunity
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Summary:	Summary Plant cell surface and intracellular immune receptors recognizing pathogen attack utilize the same defense machineries to mobilize resistance. New genetic, protein structural and biochemical information on receptor activation and signaling is transforming understanding of how their shared defense network operates. We discuss the biochemical activities of two classes of intracellular nucleotide‐binding/leucine‐rich repeat (NLR) receptor – one forming a Ca2+ channel, the other an NADase enzyme – which define engagement of enhanced disease susceptibility 1 (EDS1)‐family heterodimers and cofunctioning helper NLRs (RNLs) to connect receptor systems and amplify defenses. Toll‐interleukin‐1 receptor (TIR) domain NLR receptors and TIR‐domain proteins, with a capacity to produce NAD+‐derived small molecules, require EDS1 dimers and RNLs for defense induction. The TIR‐driven EDS1/RNL modules emerge as central elements in Ca2+‐based immunity signaling initiated by receptors outside and inside host cells. See also the Commentary on this article by Lee & Romeis, 234: 769–772.
Bibliography:	Lee & Romeis 234 769–772 See also the Commentary on this article by . ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0028-646X 1469-8137
DOI:	10.1111/nph.17924