Growth patterns of monochorionic twin pregnancy complicated by Type‐III selective fetal growth restriction

• Published in: Ultrasound in obstetrics & gynecology Vol. 59; no. 3; pp. 371 - 376
• Main Authors: Shinar, S., Xing, W., Lewi, L., Slaghekke, F., Yinon, Y., Raio, L., Baud, D., DeKoninck, P., Melamed, N., Huszti, E., Sun, L., Van Mieghem, T., Pruthi, V., Jianping, C., Couck, I., Jiang, Y., Groene, S., Lopriore, E., Batsry, L., Amylidi‐Mohr, S., Kneuss, F., Moscou, J., Barrett, J., Ryan, G.
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01-03-2022; Wiley Subscription Services, Inc
• Subjects: Complications; Discordance; Doppler; Doppler effect; Female; Fetal Growth Retardation - diagnostic imaging; Fetal Weight; Fetuses; Flow distribution; Gestation; growth; Growth disorders; Growth patterns; Gynecology; Humans; monochorionic; Obstetrics; Pregnancy; Pregnancy, Twin; Prenatal development; Retrospective Studies; selective; sFGR Type‐3; sFGR Type‐III; sIUGR; Twins; Twins, Monozygotic; Ultrasonic imaging; Ultrasonography, Prenatal; Ultrasound; Umbilical Arteries - diagnostic imaging; monochorionic; sFGR Type-III; selective; growth; sFGR Type-3; sIUGR; Doppler
• ISSN: 0960-7692; 1469-0705
• DOI: 10.1002/uog.23752

ABSTRACT
Objectives
Little is known regarding fetal growth patterns in monochorionic twin pregnancy complicated by Type‐III selective fetal growth restriction (sFGR). We aimed to assess fetal growth and umbilical artery Doppler pattern in Type‐III sFGR across gestation and evaluate the effect of changing Doppler flow pattern on growth and intertwin growth discordance.
Methods
This was a retrospective cohort study of all Type‐III sFGR pregnancies managed at nine fetal centers over a 12‐year time period. Higher‐order multiple pregnancy and cases with major fetal anomaly or other monochorionicity‐related complications at presentation were excluded. Estimated fetal weight (EFW) was assessed on ultrasound for each twin pair at five timepoints (16–20, 21–24, 25–28, 29–32 and > 32 weeks' gestation) and compared with singleton and uncomplicated monochorionic twin EFW. EFW and intertwin EFW discordance were compared between pregnancies with normalization of umbilical artery Doppler of the smaller twin later in pregnancy and those with persistently abnormal Doppler.
Results
Overall, 328 pregnancies (656 fetuses) met the study criteria. In Type‐III sFGR, the smaller twin had a lower EFW than an average singleton fetus (EFW Z‐score ranging from −1.52 at 16 weeks to −2.69 at 36 weeks) and an average monochorionic twin in uncomplicated pregnancy (Z‐score ranging from −1.73 at 16 weeks to −1.49 at 36 weeks) throughout the entire gestation, while the larger twin had a higher EFW than an average singleton fetus until 22 weeks' gestation and was similar in EFW to an average uncomplicated monochorionic twin throughout gestation. As pregnancy advanced, growth velocity of both twins decreased, with the larger twin remaining appropriately grown and the smaller twin becoming more growth restricted. Intertwin EFW discordance remained stable throughout gestation. On multivariable longitudinal modeling, normalization of fetal umbilical artery Doppler was associated with better growth of the smaller twin (P = 0.002) but not the larger twin (P = 0.1), without affecting the intertwin growth discordance (P = 0.09).
Conclusions
Abnormal fetal growth of the smaller twin in Type‐III sFGR was evident early in pregnancy, while EFW of the larger twin remained normal throughout gestation. Normalization of umbilical artery Doppler was associated with improved fetal growth of the smaller twin. © 2021 International Society of Ultrasound in Obstetrics and Gynecology.