Spectrum of epilepsy with eyelid myoclonia: Delineation of disease subtypes from a large multicenter study

• Published in: Epilepsia (Copenhagen) Vol. 64; no. 1; pp. 196 - 207
• Main Authors: Cerulli Irelli, Emanuele, Cocchi, Enrico, Ramantani, Georgia, Riva, Antonella, Caraballo, Roberto Horacio, Morano, Alessandra, Giuliano, Loretta, Yilmaz, Tülay, Panagiotakaki, Eleni, Operto, Francesca F., Giraldez, Beatriz Gonzalez, Balestrini, Simona, Silvennoinen, Katri, Casciato, Sara, Comajuan, Marion, Fortunato, Francesco, Giallonardo, Anna Teresa, Gamirova, Rimma, Coppola, Antonietta, Di Gennaro, Giancarlo, Labate, Angelo, Sofia, Vito, Kluger, Gerhard Josef, Gambardella, Antonio, Kasteleijn‐NolstTrenite, Dorothee G. A., Baykan, Betul, Sisodiya, Sanjay M., Arzimanoglou, Alexis, Striano, Pasquale, Di Bonaventura, Carlo, Fisco, Giacomo, Meletti, Stefano, Liukshina, Natalia, Tomenko, Tatiana, Gobbi, Giuseppe, Buti, Daniela, Casellato, Susanna, Striano, Salvatore, Messana, Tullio, Giordano, Lucio, Ferlazzo, Edoardo, Vignoli, Aglaia, Viri, Maurizio, Bagnasco, Irene, Bebek, Nerses, Altıokka‐Uzun, Gunes
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01-01-2023
• Subjects: classification; Cognitive ability; Comorbidity; Epilepsy; Eyelid; eyelid myoclonia with absences; Headache; idiopathic generalized epilepsy; Intellectual disabilities; Intelligence; Jeavons syndrome; juvenile myoclonic epilepsy; Migraine; Remission; Seizures; eyelid myoclonia with absences (EMA); Jeavons Syndrome; classification; idiopathic generalized epilepsy (IGE); juvenile myoclonic epilepsy (JME)
• ISSN: 0013-9580; 1528-1167
• DOI: 10.1111/epi.17450

Objective
Epilepsy with eyelid myoclonia (EEM) has been associated with marked clinical heterogeneity. Early epilepsy onset has been recently linked to lower chances of achieving sustained remission and to a less favorable neuropsychiatric outcome. However, much work is still needed to better delineate this epilepsy syndrome.
Methods
In this multicenter retrospective cohort study, we included 267 EEM patients from nine countries. Data on electroclinical and demographic features, intellectual functioning, migraine with or without aura, family history of epilepsy, and epilepsy syndromes in relatives were collected in each patient. The impact of age at epilepsy onset (AEO) on EEM clinical features was investigated, along with the distinctive clinical characteristics of patients showing sporadic myoclonia involving body regions other than eyelids (body‐MYO).
Results
Kernel density estimation revealed a trimodal distribution of AEO, and Fisher–Jenks optimization disclosed three EEM subgroups: early onset (EO‐EEM), intermediate onset (IO‐EEM), and late onset (LO‐EEM). EO‐EEM was associated with the highest rate of intellectual disability, antiseizure medication refractoriness, and psychiatric comorbidities and with the lowest rate of family history of epilepsy. LO‐EEM was associated with the highest proportion of body‐MYO and generalized tonic–clonic seizures (GTCS), whereas IO‐EEM had the lowest observed rate of additional findings. A family history of EEM was significantly more frequent in IO‐EEM and LO‐EEM compared with EO‐EEM. In the subset of patients with body‐MYO (58/267), we observed a significantly higher rate of migraine and GTCS but no relevant differences in other electroclinical features and seizure outcome.
Significance
Based on AEO, we identified consistent EEM subtypes characterized by distinct electroclinical and familial features. Our observations shed new light on the spectrum of clinical features of this generalized epilepsy syndrome and may help clinicians toward a more accurate classification and prognostic profiling of EEM patients.