Case Report: Intercurrent infections in COVID-19-induced sustained immunodepression: is interferon gamma a suitable drug?

• Published in: Frontiers in immunology Vol. 14; p. 1183665
• Main Authors: De Waard, Aurianne, Lefebvre, Laurent, Textoris, Julien, Payen, Didier
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 08-06-2023
• Subjects: acute immuno-depression syndrome; ARDS (acute respiratory disease syndrome); Coinfection - drug therapy; COVID 19; HLA-DR; HLA-DR Antigens - metabolism; Humans; Immune Tolerance; Immunology; interferon gamma (IFNγ); Interferon-gamma - pharmacology; interferon gamma (IFNγ); HLA-DR; COVID 19; ARDS (acute respiratory disease syndrome); acute immuno-depression syndrome
• ISSN: 1664-3224; 1664-3224
• DOI: 10.3389/fimmu.2023.1183665

Acute immuno-depression syndrome (AIDs) had been observed in many life-threatening conditions leading to the Intensive Care Unit. and is associated with recurrent secondary infections. We report one COVID-19 patient with a severe ARDS, demonstrating acute immunodepression syndrome lasting for several weeks. The occurrence of secondary infections despite long treatment by antibiotics led to combined interferon γ (IFNγ) as reported previously. The response to IFNγ was evaluated by the flowcytometry HLA-DR expression on circulating monocytes, which was repeated from time to time. The severe COVID-19 patients responded well to IFNγ without adverse events.