Clinical features of human salmonellosis caused by bovine-associated subtypes in New York

• Published in: Foodborne pathogens and disease Vol. 9; no. 9; p. 796
• Main Authors: Cummings, Kevin J, Warnick, Lorin D, Gröhn, Yrjö T, Hoelzer, Karin, Root, Timothy P, Siler, Julie D, McGuire, Suzanne M, Wright, Emily M, Zansky, Shelley M, Wiedmann, Martin
• Format: Journal Article
• Language: English
• Published: United States 01-09-2012
• Subjects: Animals; Bacteremia - microbiology; Bacteremia - physiopathology; Bacteremia - therapy; Case-Control Studies; Cattle - microbiology; Electrophoresis, Gel, Pulsed-Field; Female; Humans; Male; Melena - etiology; New York; Public Health Surveillance; Salmonella - classification; Salmonella - isolation & purification; Salmonella Food Poisoning - microbiology; Salmonella Food Poisoning - physiopathology; Salmonella Food Poisoning - therapy; Salmonella Infections - microbiology; Salmonella Infections - physiopathology; Salmonella Infections - therapy; Salmonella Infections, Animal - microbiology; Serotyping; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome; Zoonoses - microbiology; New York
• ISSN: 1556-7125
• DOI: 10.1089/fpd.2012.1158

The objective of this study was to identify patient symptoms and case outcomes that were more likely to occur as a result of Salmonella infections caused by bovine-associated subtypes (isolates that matched contemporary bovine isolates from New York by serovar and pulsed-field gel electrophoresis pattern), as compared to salmonellosis caused by non-bovine-associated subtypes. Data were collected in 34 counties of New York that comprise the Foodborne Diseases Active Surveillance Network (FoodNet) catchment area of the Centers for Disease Control and Prevention Emerging Infections Program. Patients with specimen collection dates between March 1, 2008 and March 1, 2010 were included. Symptoms and outcomes of 40 cases infected with bovine-associated Salmonella subtypes were compared to those of 379 control-cases infected with Salmonella isolates that were not bovine-associated. Cases were significantly more likely to have invasive salmonellosis (odds ratio, 3.8; p-value=0.02), after adjusting for age group, gender, and race. In addition, there was a marginal association between case status and the presence of blood in the stool (p-value=0.1) while ill. These findings might have implications for patient management, as a history of consuming undercooked foods of bovine origin or having direct contact with cattle in the few days prior to illness could be useful for suggesting a more proactive diagnostic approach as well as close monitoring for the need to implement more aggressive therapy.