Case report: A longitudinal study of an unusual rapidly progressive dementia case

It is daunting to determine the etiology of rapidly progressive dementia (RPD), which includes metabolic, neoplastic, infectious, autoimmune, neurodegenerative and other conditions. Herein, we illustrate an unusual case of a patient primarily exhibiting RPD, overlapping sleep dysfunction, psychosis...

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Bibliographic Details
Published in:	Frontiers in neurology Vol. 14; p. 1151130
Main Authors:	Liu, Xiaoyan, Fan, Ziqi, Chen, Xuanyu, Zhang, Yanyan, He, Fangping, Ma, Xiaohua, Ke, Qing
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 06-04-2023
Subjects:	autoimmune encephalopathy IgLON5 immunotherapy Neurology psychosis rapidly progressive dementia rapidly progressive dementia IgLON5 autoimmune encephalopathy psychosis immunotherapy
Online Access:	Get full text
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Summary:	It is daunting to determine the etiology of rapidly progressive dementia (RPD), which includes metabolic, neoplastic, infectious, autoimmune, neurodegenerative and other conditions. Herein, we illustrate an unusual case of a patient primarily exhibiting RPD, overlapping sleep dysfunction, psychosis and abnormal movement, which was finally defined as anti-IgLON5 disease, a novel and rare autoimmune encephalopathy. Furthermore, we longitudinally described his cognitive and psychological performance in detail, and determined that early initiation of immunotherapy in this patient did not result in a good outcome. These data highlight anti-IgLON5 disease as a possible differential diagnosis in patients with RPD.
Bibliography:	These authors have contributed equally to this work Reviewed by: Simone Baiardi, University of Bologna, Italy; Vivek Lal, Post Graduate Institute of Medical Education and Research (PGIMER), India This article was submitted to Dementia and Neurodegenerative Diseases, a section of the journal Frontiers in Neurology Edited by: Bruce Miller, University of California, San Francisco, United States
ISSN:	1664-2295 1664-2295
DOI:	10.3389/fneur.2023.1151130