Automatic application of ICRP biokinetic models in voxel phantoms for in vivo counting and internal dose assessment

• Published in: Radiation protection dosimetry Vol. 127; no. 1-4; pp. 240 - 244
• Main Authors: Lamart, S., de Carlan, L., Blanchardon, E., Franck, D.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01-01-2007; Oxford University Press (OUP)
• Subjects: Algorithms; Biological Assay - methods; Computer Simulation; Humans; Internationality; Kinetics; Life Sciences; Models, Biological; Organ Specificity; Radiation Dosage; Relative Biological Effectiveness; Sensitivity and Specificity; Tissue Distribution; Whole-Body Counting - methods; dosimetry; Whole-Body Counting; nuclear magnetic resonance imaging; anthropometry; Humans; whole body counting; international cooperation; computer interface; radiation dose distribution; tissue distribution; automation; antibody specificity; radiation hazard; radiation protection; computer simulation; radiation absorption; Biological Assay; radiation dose; calibration; computer assisted tomography; human; algorithm; Monte Carlo method; validation process; biological model; bioassay; mathematical analysis; Biological; Radiation Dosage; Organ Specificity; article; sensitivity and specificity; phantom; Algorithms; mathematical computing; Internationality; relative biologic effectiveness; mathematical model; prediction; computer program; Models; Relative Biological Effectiveness; kinetics; methodology; americium 241; radioisotope
• ISSN: 0144-8420; 1742-3406
• DOI: 10.1093/rpd/ncm345

As part of the improvement of calibration techniques of in vivo counting, the Laboratory of Internal Dose Assessment of the Institute of Radiological Protection and Nuclear Safety has developed a computer tool, ‘OEDIPE’, to model internal contamination, to simulate in vivo counting and to calculate internal dose. The first version of this software could model sources located in a single organ. As the distribution of the contamination evolves from the time of intake according to the biokinetics of the radionuclide, a new facility has been added to the software first to allow complex heterogeneous source modelling and then to automatically integrate the distribution of the contamination in the different tissues estimated by biokinetic calculation at any time since the intake. These new developments give the opportunity to study the influence of the biokinetics on the in vivo counting, leading to a better assessment of the calibration factors and the corresponding uncertainties.