Hypericum triquetrifolium Turra. extract exhibits antiinflammatory activity in the rat

• Published in: Journal of ethnopharmacology Vol. 80; no. 2-3; pp. 207 - 209
• Main Authors: OZTURK, Bintug, APAYDIN, Sebnem, GOLDELI, Esin, INCE, Iskender, ZEYBEK, Ulvi
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier 01-05-2002
• Subjects: Animals; Anti-Inflammatory Agents - therapeutic use; Biological and medical sciences; Carrageenan; Edema - chemically induced; Edema - drug therapy; General pharmacology; Hypericum; Male; Medical sciences; Methanol; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phytotherapy; Plant Extracts - therapeutic use; Rats; Rats, Wistar; Solvents; Edema; Intraperitoneal administration; Rat; Pharmacognosy; Guttiferae; Rodentia; Antiinflammatory agent; Extract; Inflammation; Medicinal plant; Vertebrata; Mammalia; Treatment; Folk medicine; Dicotyledones; Animal; Angiospermae; Plant origin; Spermatophyta; Phytotherapy
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/S0378-8741(02)00044-2

The aim of the present study was to explore the probable antiinflammatory effect of Hypericum triquetrifolium Turra. in a rat model of carrageenan induced inflammation. Male Wistar rats were treated intraperitoneally with 0.4% dimethylsulphoxide (DMSO) (as control group) and H. triquetrifolium extract (25, 50, 60 mg/kg), 30 min before 0.1 ml 1% carrageenan injection. Paw volume was measured before and 1, 2, 3, 4, 5 and 6 h after the injection of carrageenan. The results are expressed as the mean+/-s.e. mean and the statistical significance of differences between groups was analyzed by One Way Analysis of Variance (ANOVA). The intraplantar injection of carrageenan caused a time-dependent paw edema in the rat although saline injection caused no swelling. Intraperitoneal administration of H. triquetrifolium extract (25, 50, 60 mg/kg) inhibited paw swelling dose-dependently at 2, 3, 4, 5 and 6 h after carrageenan injection (P<0.05). We can conclude that H. triquetrifolium extract may exert an antiinflammatory effect in rats.