FOXO transcription factors: key regulators of cell fate

FOXO (forkhead box O) transcription factors are crucial regulators of cell fate. This function of FOXO proteins relies on their ability to control diverse and at times, opposing cellular functions, such as proliferation, differentiation, DNA repair, defence against oxidative stress damage and apopto...

Full description

Saved in:

Bibliographic Details
Published in:	Biochemical Society transactions Vol. 34; no. Pt 5; p. 722
Main Authors:	Lam, E W-F, Francis, R E, Petkovic, M
Format:	Journal Article
Language:	English
Published:	England 01-11-2006
Subjects:	Cell Cycle - physiology Cell Nucleus - physiology Cell Physiological Phenomena Cell Survival - physiology Cytoplasm - physiology Forkhead Transcription Factors - physiology Homeostasis Humans Proto-Oncogene Proteins c-akt - metabolism Transcription Factors - metabolism
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	FOXO (forkhead box O) transcription factors are crucial regulators of cell fate. This function of FOXO proteins relies on their ability to control diverse and at times, opposing cellular functions, such as proliferation, differentiation, DNA repair, defence against oxidative stress damage and apoptosis, in response to hormones, growth factors and other environmental cues. This review discusses our current understanding of the regulation and role of FOXO transcription factors in determining cell fate and highlights their relevance to tumorigenesis and drug resistance.
ISSN:	0300-5127
DOI:	10.1042/bst0340722