Microchip Electrophoresis Tools for the Analysis of Small Molecules

Microchip electrophoresis (ME) results from miniaturization of capillary electrophoresis (CE) to a microfabricated separation device. Both techniques have common characteristics, but in some aspects, the microfluidic separation device has unique features resulting from its planar miniaturized format...

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Bibliographic Details
Published in:	Methods in molecular biology (Clifton, N.J.) Vol. 1906; p. 197
Main Authors:	Gomez, Federico J V, Silva, María Fernanda
Format:	Journal Article
Language:	English
Published:	United States 01-01-2019
Subjects:	Alkaloids - analysis Amino Acids - analysis Electrophoresis, Microchip - instrumentation Equipment Design Microfluidic Analytical Techniques - instrumentation Phenols - analysis Small Molecule Libraries - analysis Indolamines Lab-on-a-chip separations Capillary zone electrophoresis Phenolic compounds
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Summary:	Microchip electrophoresis (ME) results from miniaturization of capillary electrophoresis (CE) to a microfabricated separation device. Both techniques have common characteristics, but in some aspects, the microfluidic separation device has unique features resulting from its planar miniaturized format. Here we describe the process to transfer of CE to ME and the benefits and drawbacks of the chip with respect to the capillary. A practical guide for method development on the microchip for small ionizable molecules such as phenolic compounds, amino acids, or alkaloids is also presented.
ISSN:	1940-6029
DOI:	10.1007/978-1-4939-8964-5_13