Association between Helicobacter pylori infection and cirrhosis in patients with chronic hepatitis C virus

We evaluated, employing a logistic regression model, the association between Helicobacter pylori infection and cirrhosis in a cohort of 106 patients (57 males; mean age, 52.9 years; range, 20-78 years) with chronic hepatitis C virus (HCV) from Rosario, Argentina. HCV was confirmed by ELISA and PCR....

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Published in:Digestive diseases and sciences Vol. 51; no. 2; pp. 370 - 373
Main Authors: MAGALHAES QUEIROZ, Dulciene Maria, CAMARGOS ROCHA, Andreia Maria, ROCHA, Gifone Aguiar, SINGULANO CINQUE, Sarah Maria, OLIVEIRA, Adriana Goncalves, GODOY, Alicia, TANNO, Hugo
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Language:English
Published: Heidelberg Springer 01-02-2006
Springer Nature B.V
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Abstract We evaluated, employing a logistic regression model, the association between Helicobacter pylori infection and cirrhosis in a cohort of 106 patients (57 males; mean age, 52.9 years; range, 20-78 years) with chronic hepatitis C virus (HCV) from Rosario, Argentina. HCV was confirmed by ELISA and PCR. H. pylori status was determined by ELISA. Of the 106 patients evaluated, 47 (44.3%) had cirrhosis. A total of 70.2% (33/47) of cirrhotic patients and 47.5% (28/59) of noncirrhotic patients were H. pylori-positive. In univariate analyses, cirrhosis was associated with age (P = 0.016) and H. pylori-positive status (P = 0.019) but not with gender (P = 0.28) or length of infection (P = 0.35). In multivariate analysis, H. pylori infection (P = 0.037; OR = 2.42; 95% CI = 1.06-5.53) and age (P = 0.033; OR = 1.04; 95% CI = 1.00-1.07) of patients remained significant and independently associated with cirrhosis. In conclusion, our results demonstrate an association between H. pylori infection and cirrhosis in patients with hepatitis C virus.
AbstractList We evaluated, employing a logistic regression model, the association between Helicobacter pylori infection and cirrhosis in a cohort of 106 patients (57 males; mean age, 52.9 years; range, 20-78 years) with chronic hepatitis C virus (HCV) from Rosario, Argentina. HCV was confirmed by ELISA and PCR. H. pylori status was determined by ELISA. Of the 106 patients evaluated, 47 (44.3%) had cirrhosis. A total of 70.2% (33/47) of cirrhotic patients and 47.5% (28/59) of noncirrhotic patients were H. pylori-positive. In univariate analyses, cirrhosis was associated with age (P = 0.016) and H. pylori-positive status (P = 0.019) but not with gender (P = 0.28) or length of infection (P = 0.35). In multivariate analysis, H. pylori infection (P = 0.037; OR = 2.42; 95% CI = 1.06-5.53) and age (P = 0.033; OR = 1.04; 95% CI = 1.00-1.07) of patients remained significant and independently associated with cirrhosis. In conclusion, our results demonstrate an association between H. pylori infection and cirrhosis in patients with hepatitis C virus.
Author ROCHA, Gifone Aguiar
GODOY, Alicia
TANNO, Hugo
SINGULANO CINQUE, Sarah Maria
OLIVEIRA, Adriana Goncalves
MAGALHAES QUEIROZ, Dulciene Maria
CAMARGOS ROCHA, Andreia Maria
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  givenname: Dulciene Maria
  surname: MAGALHAES QUEIROZ
  fullname: MAGALHAES QUEIROZ, Dulciene Maria
  organization: Laboratory of Research in Bacteriology. Faculdade de Medicina. Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
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  givenname: Andreia Maria
  surname: CAMARGOS ROCHA
  fullname: CAMARGOS ROCHA, Andreia Maria
  organization: Laboratory of Research in Bacteriology. Faculdade de Medicina. Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
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  givenname: Gifone Aguiar
  surname: ROCHA
  fullname: ROCHA, Gifone Aguiar
  organization: Laboratory of Research in Bacteriology. Faculdade de Medicina. Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
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  givenname: Sarah Maria
  surname: SINGULANO CINQUE
  fullname: SINGULANO CINQUE, Sarah Maria
  organization: Laboratory of Research in Bacteriology. Faculdade de Medicina. Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
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  givenname: Adriana Goncalves
  surname: OLIVEIRA
  fullname: OLIVEIRA, Adriana Goncalves
  organization: Faculdade de Medicina do Triângulo Mineiro, Brazil
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  givenname: Alicia
  surname: GODOY
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  organization: Servicio de Gastroenterologia del Hospital Centenario, Universidad Nacional de Rosario, Rosario, Argentina
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  givenname: Hugo
  surname: TANNO
  fullname: TANNO, Hugo
  organization: Servicio de Gastroenterologia del Hospital Centenario, Universidad Nacional de Rosario, Rosario, Argentina
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IsPeerReviewed true
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Issue 2
Keywords Human
hepatitis C virus: cirrhosis
Spirillales
Spirillaceae
Hepatic disease
Metabolic diseases
Infection
Virus
Cirrhosis
pathogenesis
Helicobacter pylori
Viral disease
Gastroenterology
Digestive diseases
Bacteria
Flaviviridae
Hepatitis C virus
Hepacivirus
Viral hepatitis C
Language English
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Snippet We evaluated, employing a logistic regression model, the association between Helicobacter pylori infection and cirrhosis in a cohort of 106 patients (57 males;...
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SubjectTerms Adult
Age Factors
Aged
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Biological and medical sciences
Cohort Studies
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Gastroenterology. Liver. Pancreas. Abdomen
Helicobacter Infections - complications
Helicobacter Infections - diagnosis
Helicobacter pylori
Hepatitis C virus
Hepatitis C, Chronic - microbiology
Human bacterial diseases
Humans
Infectious diseases
Liver Cirrhosis - microbiology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Logistic Models
Male
Medical sciences
Middle Aged
Odds Ratio
Other diseases. Semiology
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Title Association between Helicobacter pylori infection and cirrhosis in patients with chronic hepatitis C virus
URI https://www.ncbi.nlm.nih.gov/pubmed/16534683
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