Association between Helicobacter pylori infection and cirrhosis in patients with chronic hepatitis C virus

• Published in: Digestive diseases and sciences Vol. 51; no. 2; pp. 370 - 373
• Main Authors: MAGALHAES QUEIROZ, Dulciene Maria, CAMARGOS ROCHA, Andreia Maria, ROCHA, Gifone Aguiar, SINGULANO CINQUE, Sarah Maria, OLIVEIRA, Adriana Goncalves, GODOY, Alicia, TANNO, Hugo
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01-02-2006; Springer Nature B.V
• Subjects: Adult; Age Factors; Aged; Bacterial diseases; Bacterial diseases of the digestive system and abdomen; Biological and medical sciences; Cohort Studies; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Gastroenterology. Liver. Pancreas. Abdomen; Helicobacter Infections - complications; Helicobacter Infections - diagnosis; Helicobacter pylori; Hepatitis C virus; Hepatitis C, Chronic - microbiology; Human bacterial diseases; Humans; Infectious diseases; Liver Cirrhosis - microbiology; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Logistic Models; Male; Medical sciences; Middle Aged; Odds Ratio; Other diseases. Semiology; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Human; hepatitis C virus: cirrhosis; Spirillales; Spirillaceae; Hepatic disease; Metabolic diseases; Infection; Virus; Cirrhosis; pathogenesis; Helicobacter pylori; Viral disease; Gastroenterology; Digestive diseases; Bacteria; Flaviviridae; Hepatitis C virus; Hepacivirus; Viral hepatitis C
• ISSN: 0163-2116; 1573-2568
• DOI: 10.1007/s10620-006-3150-y

We evaluated, employing a logistic regression model, the association between Helicobacter pylori infection and cirrhosis in a cohort of 106 patients (57 males; mean age, 52.9 years; range, 20-78 years) with chronic hepatitis C virus (HCV) from Rosario, Argentina. HCV was confirmed by ELISA and PCR. H. pylori status was determined by ELISA. Of the 106 patients evaluated, 47 (44.3%) had cirrhosis. A total of 70.2% (33/47) of cirrhotic patients and 47.5% (28/59) of noncirrhotic patients were H. pylori-positive. In univariate analyses, cirrhosis was associated with age (P = 0.016) and H. pylori-positive status (P = 0.019) but not with gender (P = 0.28) or length of infection (P = 0.35). In multivariate analysis, H. pylori infection (P = 0.037; OR = 2.42; 95% CI = 1.06-5.53) and age (P = 0.033; OR = 1.04; 95% CI = 1.00-1.07) of patients remained significant and independently associated with cirrhosis. In conclusion, our results demonstrate an association between H. pylori infection and cirrhosis in patients with hepatitis C virus.