Effect on osseointegration of two implant macro-designs:A histomorphometric analysis of bicortically installed implants in different topographic sites of rabbit's tibiae

• Published in: Medicina oral, patología oral y cirugía bucal Vol. 24; no. 4; pp. e502 - e510
• Main Authors: Soto-Peñaloza, D, Caneva, M, Viña-Almunia, J, Martin-de-Llano, J-J, García-Mira, B, Peñarrocha-Oltra, D, Botticelli, D, Peñarrocha-Diago, M
• Format: Journal Article
• Language: English
• Published: Spain Medicina Oral S.L 01-07-2019
• Subjects: Animals; Dental Implantation, Endosseous; Dental Implants; Osseointegration; Rabbits; Spain; Surface Properties; Tibia; Titanium; Spain
• ISSN: 1698-6946; 1698-4447; 1698-6946
• DOI: 10.4317/medoral.22825

To evaluate the effect of two different implant macro-designs on the sequential osseointegration at bicortically installed implants in the rabbit tibia. A further aim is to compare the osseointegration at different topographic zones.
27 New Zealand rabbits were implemented. Two implants, one for each macro-design (Ticare Inhex® or Ticare Quattro®, Mozo-Grau, Valladolid, Spain), were randomly implanted in the diaphysis or metaphysis of each tibia. The flaps were sutured to allow a submerged healing. The animals were sacrificed after 2, 4 or 8 weeks. Ground sections were prepared and analyzed.
No statistically significant differences were found between the two groups for newly formed bone in contact with the implant surface, being about 16%, 19% and 33% in both groups, after 2, 4, and 8 weeks of healing. Bone apposition was slightly higher in the diaphysis, reaching values of 36.4% in the diaphysis, and 29.3% in the metaphysis at 8 weeks of healing. It was observed that the implant position showed a statistical significance regarding BIC values at 4 and 8 weeks (p<0.05). Multivariate analysis fails to detect statistical significant differences for the interaction between implant designs and topographic site. Ticare Quattro® design had a slight better BIC values at diaphysis sites across healing stages, but without reaching a statistical significance.
The both implant macro-designs provided similar degrees of osseointegration. Bone morphometry and density may affect bone apposition onto the implant surface. The apposition rates were slightly better in diaphysis compared to metaphysis.