Accuracy and precision of tissue optical properties and hemodynamic parameters estimated by the BabyLux device: a hybrid time-resolved near-infrared and diffuse correlation spectroscopy neuro-monitor

• Published in: Biomedical optics express Vol. 10; no. 5; pp. 2556 - 2579
• Main Authors: Giovannella, Martina, Spinelli, Lorenzo, Pagliazzi, Marco, Contini, Davide, Greisen, Gorm, Weigel, Udo M, Torricelli, Alessandro, Durduran, Turgut
• Format: Journal Article
• Language: English
• Published: United States Optical Society of America 01-05-2019
• ISSN: 2156-7085; 2156-7085
• DOI: 10.1364/BOE.10.002556

We have investigated the accuracy and precision of "the BabyLux device", a hybrid time-resolved near-infrared (TRS) and diffuse correlation spectroscopy (DCS) neuro-monitor for the pre-term infant. Numerical data with realistic noise were simulated and analyzed using the BabyLux device as a reference system and different experimental and analysis parameters. The results describe the limits for the precision and the accuracy to be expected. The dependence of these limits on different experimental conditions and choices of the analysis method is also described. Experiments demonstrate comparable values for precision with respect to the simulation results.