Early assessment of lateralization and sex influences on the microstructure of the white matter corticospinal tract in healthy term neonates

• Published in: Journal of neuroscience research Vol. 97; no. 4; pp. 480 - 491
• Main Authors: Saadani‐Makki, Fadoua, Hagmann, Cornelia, Balédent, Olivier, Makki, Malek I.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01-04-2019; Wiley
• Subjects: Anisotropy; Children & youth; corticospinal tract; Diffusion coefficient; DTI; fiber tracking; Fibers; Gender aspects; Girls; Hemispheric laterality; Infants; lateralization; Life Sciences; Magnetic resonance imaging; Neonates; Neurodevelopment; Pons; Pyramidal tracts; Segments; Sex; Sex differences; Substantia alba; Tensors; DTI; lateralization; neonates; corticospinal tract; sex; fiber tracking
• ISSN: 0360-4012; 1097-4547
• DOI: 10.1002/jnr.24359

We assessed the sex and the lateralization differences in the corticospinal tract (CST) during the early postnatal period. Twenty‐five healthy term neonates (13 girls, aged 39.2 ± 1.2 weeks, and 12 boys aged 38.6 ± 3.0 weeks) underwent Diffusion Tensor Imaging (DTI). Fiber tracking was performed to extract bilaterally the CST pathways and to quantify the parallel (E1) and perpendicular (E23) diffusions, the apparent diffusion coefficient (ADC), and fractional anisotropy (FA). The measurements were performed on the entire CST fibers and on four segments: base of the pons (CST‐Po), cerebral peduncles (CST‐CP), posterior limb of the internal capsule (CST‐PLIC), and corona‐radiata (CST‐CR). Significantly higher E1, lower E23, and higher FA in the right compared to the left were noted in the CST‐PLIC of the girls. Significantly lower E23 and lower ADC with higher FA in the right compared to left were observed in the CST‐CP of the boys. Moreover, the CST‐PLIC of the boys had significantly higher E1 in the right compared to the left. There was a significant increase in left CST E1 of boys when compared with girls. Girls had a significantly lower E1, lower E23 and, lower ADC in the left CST‐CP compared with boys. In addition, girls had a significantly lower E23 and higher FA in the right CST‐PLIC compared with boys. Sex differences and lateralization in structure‐based segments of the CST were found in healthy term infants during early postnatal period. These findings are vital to understanding motor development of healthy term born neonates to better interpret newborn infants with abnormal neurodevelopment.
Diffusion indices of the entire CST and its segmentation on healthy term born neonate boys and girls demonstrate specific spatial differences and significant side and sex influences as expressed by the parallel and perpendicular diffusion, the apparent diffusion coefficient, and anisotropy.