Suppression of simian immunodeficiency virus replication in vitro by CD8+ lymphocytes

• Published in: The Journal of immunology (1950) Vol. 140; no. 7; pp. 2237 - 2242
• Main Authors: Kannagi, M, Chalifoux, LV, Lord, CI, Letvin, NL
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Am Assoc Immnol 01-04-1988; American Association of Immunologists
• Subjects: AIDS-Related Complex - immunology; AIDS-Related Complex - microbiology; AIDS-Related Complex - pathology; AIDS/HIV; Animals; Antigens, Differentiation, T-Lymphocyte - immunology; Biological and medical sciences; Cell Line; Fundamental and applied biological sciences. Psychology; Leukocyte Count; Lymphocyte Activation; Macaca - immunology; Macaca mulatta - immunology; Microbiology; Phenotype; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains; Retroviridae - growth & development; Retroviridae - immunology; T-Lymphocytes, Regulatory - classification; T-Lymphocytes, Regulatory - immunology; Virology; Virus Replication; Cell culture; Immunopathology; Animal model; Virus multiplication; Monkey; Retroviridae; AIDS; Hemopathy; Experimental animal; In vitro; Host virus relation; Cell subpopulation; Infection; Virus; Vertebrata; Experimental disease; Mammalia; Viral disease; T-Lymphocyte; Primates; Inhibition; Simian immunodeficiency virus; Lymphocyte
• ISSN: 0022-1767; 1550-6606
• DOI: 10.4049/jimmunol.140.7.2237

The AIDS-like disease in rhesus monkeys induced by the simian immunodeficiency virus (SIV) has been used as a model to explore the nature of the T lymphocyte response after infection with viruses of the human immunodeficiency virus family. Activated CD8+ lymphocytes are present in increased numbers in the paracortex of lymph nodes of SIV-infected rhesus monkeys with a lymphadenopathy syndrome. We demonstrate that SIV is more readily isolated from CD8+ lymphocyte-depleted PBL of SIV-infected animals than from their unfractionated PBL. Rather than reflecting the fact that the CD8+ lymphocyte-depleted cell populations are simply enriched for CD4+ lymphocytes, this indicates that CD8+ cells themselves are critical in this regulatory interaction. In fact, CD8+ lymphocytes from SIV-infected but not uninfected rhesus monkeys can block SIV replication in vitro in PBL populations. A T lymphocyte population that blocks replication of viruses of the HIV family may contribute to containing the progression of AIDS.