Genomic microarrays: a technology overview

ABSTRACT Genomic microarrays are now widely used diagnostically for the molecular karyotyping of patients with intellectual disability, congenital anomalies and autistic spectrum disorder and have more recently been applied for the detection of genomic imbalances in prenatal genetic diagnosis. We pr...

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Bibliographic Details
Published in:	Prenatal diagnosis Vol. 32; no. 4; pp. 336 - 343
Main Authors:	Brady, Paul D., Vermeesch, Joris R.
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 01-04-2012
Subjects:	Adult Amniocentesis - methods Amniotic Fluid - chemistry Amniotic Fluid - cytology Array CGH Chromosome Aberrations Chromosome Disorders - diagnosis Chromosome Disorders - genetics Comparative Genomic Hybridization Copy Number Variation DNA Female Gene Expression Profiling General cytogenetics Genome, Human Genomic Arrays Genomics Humans Microarray Analysis - methods Molecular Diagnostic Techniques Oligonucleotide Array Sequence Analysis - methods Pregnancy SNP array
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Summary:	ABSTRACT Genomic microarrays are now widely used diagnostically for the molecular karyotyping of patients with intellectual disability, congenital anomalies and autistic spectrum disorder and have more recently been applied for the detection of genomic imbalances in prenatal genetic diagnosis. We present an overview of the different arrays, protocols used and discuss methods of genomic array data analysis. © 2012 John Wiley & Sons, Ltd.
Bibliography:	ark:/67375/WNG-V9QTV3Q9-V istex:9D1E445AA827A83EA4553388D1668AC792694363 ArticleID:PD2933 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0197-3851 1097-0223
DOI:	10.1002/pd.2933