Plasma angiotensin(1-7) immunoreactivity is increased by salt load, water deprivation, and hemorrhage

• Published in: Peptides (New York, N.Y. : 1980) Vol. 15; no. 4; p. 723
• Main Authors: Botelho, L M, Block, C H, Khosla, M C, Santos, R A
• Format: Journal Article
• Language: English
• Published: United States 1994
• Subjects: Angiotensin I; Angiotensin II - blood; Animals; Hemorrhage - blood; Male; Peptide Fragments - blood; Radioimmunoassay; Rats; Rats, Wistar; Sodium Chloride - adverse effects; Water Deprivation - physiology; Water-Electrolyte Imbalance - blood
• ISSN: 0196-9781
• DOI: 10.1016/0196-9781(94)90103-1

In this study we investigated the effects of dehydration and hemorrhage on circulating levels of the heptapeptide, angiotensin(1-7). In water-deprived rats, a twofold increase in plasma angiotensin(1-7) was associated with similar increases in plasma renin activity, and angiotensin I and angiotensin II levels. In salt-loaded rats, plasma angiotensin(1-7) levels increased fourfold; however, other components of the renin-angiotensin system were suppressed or unchanged. In salt-loaded rats, increases in plasma angiotensin II levels in response to hemorrhage in normal rats were severely blunted, whereas angiotensin(1-7) plasma levels increased proportionately to the loss of blood volume. These results suggest that angiotensin(1-7) plasma concentration can be selectively regulated during dehydration and hemorrhage.