The spatial QRS-T angle as a marker of ventricular repolarisation in hypertension

• Published in: Journal of human hypertension Vol. 15; no. 1; pp. 63 - 70
• Main Authors: DILAVERIS, P, GIALAFOS, E, PANTAZIS, A, SYNETOS, A, TRIPOSKIADIS, F, GIALAFOS, J
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing 2001; Nature Publishing Group
• Subjects: Aged; Antihypertensive Agents - therapeutic use; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Blood Pressure; Cardiology. Vascular system; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Electrocardiography; Electrophysiology; Female; Humans; Hypertension - drug therapy; Hypertension - physiopathology; Male; Medical sciences; Middle Aged; Vectorcardiography; Ventricular Function; Human; Hypertension; QT interval; Cardiovascular disease; Prognosis; Vectorcardiography
• ISSN: 0950-9240; 1476-5527
• DOI: 10.1038/sj.jhh.1001129

Ventricular repolarisation abnormalities are important in arrhythmia provocation. The dispersion of repolarisation duration is not the only aspect of repolarisation heterogeneity. Spatial vectorcardiographic descriptors constitute a novel approach to quantify ventricular repolarisation. To test the ability of vectorcardiographic descriptors to discriminate between hypertensives with high or low blood pressure (BP), 110 treated hypertensives (mean age 63.6 +/- 12.1 years) were classified in the high (systolic BP > or = 160 mm Hg or diastolic BP > or = 95 mm Hg) (n = 67), or the low (systolic BP < 160 mm Hg and diastolic BP <95 mm Hg) (n = 43) BP group. The maximum QT, JT, and T peak-T end intervals and the QT, JT, and T peak--T end dispersion were calculated from a digitally recorded 12-lead electrocardiogram (ECG). X, Y, and Z leads were reconstructed from the 12-lead ECG. The amplitude of the maximum spatial T vector (spatial T amplitude), the angle between the maximum spatial QRS and T vectors (spatial QRS-T angle) and the frontal plane QRS-T angle were calculated. The spatial QRS-T angle was higher in patients with high compared to those with low BP (P = 0.025). All conventional ECG markers of the dispersion of ventricular repolarisation duration failed to demonstrate significant differences between hypertensives with high or low BP. In conclusion, the spatial QRS-T angle was significantly increased in those treated hypertensive patients who showed repeatedly high BP values. Hence, we may suggest that the angle between the directions of ventricular depolarisation and repolarisation is a sensitive marker of the repolarisation alterations in systemic hypertension. Journal of Human Hypertension (2001) 15, 63-70