Naltrexone prevents footshock-induced performance deficit in rats

Three experiments demonstrate that inescapable footshock delivered to unrestrained rats produces analgesia as well as performance deficits in subsequent one-way shuttle acquisition. Both the performance and the antinociceptive effects are prevented by pretreatment with as little as 0.1 mg/kg i.p. of...

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Bibliographic Details
Published in:	Life sciences (1973) Vol. 34; no. 21; p. 2057
Main Authors:	McCubbin, J A, Kizer, J S, Lipton, M A
Format:	Journal Article
Language:	English
Published:	Netherlands 21-05-1984
Subjects:	Analgesia Animals Avoidance Learning - drug effects Electroshock Male Naloxone - analogs & derivatives Naltrexone - pharmacology Rats Rats, Inbred Strains Receptors, Opioid - physiology
Online Access:	Get more information
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Summary:	Three experiments demonstrate that inescapable footshock delivered to unrestrained rats produces analgesia as well as performance deficits in subsequent one-way shuttle acquisition. Both the performance and the antinociceptive effects are prevented by pretreatment with as little as 0.1 mg/kg i.p. of the opiate antagonist, naltrexone. These studies suggest that both effects are mediated through opiate receptors with similar underlying naltrexone pharmaco-dynamics.
ISSN:	0024-3205
DOI:	10.1016/0024-3205(84)90370-9