Variations in HDL and VLDL levels chronic alcoholics. Influence of the degree of liver damage and of withdrawal of alcohol

Changes in plasma HDL and VLDL levels were investigated in 284 chronic alcoholics staying in a Detoxification Centre where they initiated or continued abstinence. The data show that the variations in plasma HDL are modulated by the degree of liver injury. In severe hepatic damage HDL levels are shar...

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Bibliographic Details
Published in:	Clinica chimica acta Vol. 148; no. 3; p. 211
Main Authors:	Tateossian, S, Peynet, J G, Legrand, A G, Collet, B, Rossignol, J A, Delattre, J J, Rousselet, F J
Format:	Journal Article
Language:	English
Published:	Netherlands 14-06-1985
Subjects:	Alcoholism - blood Alcoholism - pathology Cholesterol, HDL - blood Ethanol - adverse effects Humans Lipids - blood Lipoproteins, HDL - blood Lipoproteins, VLDL - blood Liver - pathology Phospholipids - blood Substance Withdrawal Syndrome - blood
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Summary:	Changes in plasma HDL and VLDL levels were investigated in 284 chronic alcoholics staying in a Detoxification Centre where they initiated or continued abstinence. The data show that the variations in plasma HDL are modulated by the degree of liver injury. In severe hepatic damage HDL levels are sharply decreased. An alcohol-induced rise in HDL can occur in the only subjects with no signs of hepatic insufficiency. This elevation is rapidly reversible after withdrawal of alcohol. Such a rise might reflect enhanced synthesis and release by liver but might also be due to an accelerated turnover of the VLDL.
ISSN:	0009-8981
DOI:	10.1016/0009-8981(85)90147-0