Doppler velocimetry and behavioural state development in relation to perinatal outcome in pregnancies complicated by gestational diabetes

• Published in: Early human development Vol. 41; no. 3; pp. 193 - 201
• Main Authors: Gazzolo, D., Scopesi, F., Russo, A., Camoriano, R., Santi, F., Di Renzo, G.C., Visser, G.H.A., Bruschettini, P.L.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Lausanne Elsevier Ireland Ltd 28-04-1995; New York,NY Elsevier; Amsterdam
• Subjects: Behavior; Biological and medical sciences; Diabetes, Gestational - physiopathology; Diseases of mother, fetus and pregnancy; Female; Fetus - physiology; Gestational Age; Gynecology. Andrology. Obstetrics; Humans; Laser-Doppler Flowmetry; Medical sciences; Nervous System Diseases - etiology; Pregnancy; Pregnancy Outcome; Pregnancy. Fetus. Placenta; Endocrinopathy; Sonography; Doppler ultrasound study; Pregnancy; Human; Embryonic development; Diabetes mellitus; Risk factor; Perinatal; Fetus; Behavior; Maternal diseases
• ISSN: 0378-3782; 1872-6232
• DOI: 10.1016/0378-3782(95)01627-F

Seventy-one pregnancies complicated by gestational diabetes and 100 healthy pregnancies were monitored on two occasions (between 27th–32nd and 33rd–36th week of gestation) by behavioural state analysis (1F coincidence; 2F coincidence) and umbilical artery Doppler velocimetry (UA) (Resistance Index, RI). The purpose of our study was to determine if the development of behavioural states and Doppler velocimetry: (1) differ between normal and gestational diabetic cases; (2) in gestational diabetic cases, are they related to the degree of abnormality of the maternal oral glucose tolerance test (OGTT)?; and (3) are they predictors of perinatal outcome? (i.e. emergency caesarean section; low Apgar scores; respiratory distress syndrome; neonatal hypoglycaemia and neurological abnormality in the neonate and/or at 4 months of age). Our findings suggest that: (1) results on behavioural state development and Doppler velocimetry were significantly different in gestational diabetic cases; (2) infants of women with gestational diabetes who are neurologically abnormal during the newborn period, had a poor development of coincidence 2F during fetal life and had neonatal hypoglycaemia more often than infants with a normal neurological outcome; (3) in cases with abnormal neurological outcome, the maternal diabetes was more severe than in those cases with normal outcome.