Screening for Glucose Metabolism Disorders, Assessment the Disse Insulin Resistance Index and Hospital Prognosis of Coronary Artery Bypass Surgery

• Published in: Journal of personalized medicine Vol. 11; no. 8; p. 802
• Main Authors: Sumin, Alexey N., Bezdenezhnykh, Natalia A., Bezdenezhnykh, Andrey V., Osokina, Anastasia V., Kuz’mina, Anastasiya A., Tsepokina, Anna V., Barbarash, Olga L.
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 17-08-2021; MDPI
• Subjects: Aorta; Carbohydrate metabolism; Carbohydrates; Cardiovascular disease; Comorbidity; Coronary artery; Coronary vessels; Creatinine; Diabetes; Diabetes mellitus (non-insulin dependent); Fatty acids; Glucose; Glucose metabolism; Heart attacks; Heart failure; Heart surgery; Hemoglobin; Hyperglycemia; Insulin; Insulin resistance; Kidneys; Medical prognosis; Metabolic disorders; Mortality; Patients; Precision medicine
• ISSN: 2075-4426; 2075-4426
• DOI: 10.3390/jpm11080802

Objective: To study insulin resistance markers and their relationship with preoperative status and hospital complications of coronary artery bypass grafting (CABG) in patients with type 2 diabetes, prediabetes and normoglycemia. Methods: We included 383 consecutive patients who underwent CABG. Patients were divided into two groups—with carbohydrate metabolism disorders (CMD, n = 192) and without CMD (n = 191). Free fatty acids and fasting insulin in plasma were determined, and the Disse, QUICKI and revised QUICKI indices were calculated in all patients. Perioperative characteristics and postoperative complications were analyzed in these groups, and their relations with markers of insulin resistance. Results: Screening before CABG increased the number of patients with CMD from 25.3% to 50.1%. Incidence of postoperative stroke (p = 0.044), and hospital stay after CABG > 30 days (p = 0.014) was greater in CMD patients. Logistic regression analysis revealed that an increase in left atrial size, age, aortic clamping time, and decrease in Disse index were independently associated with hospital stay >10 days and/or perioperative complications. Conclusions: Screening for CMD before CABG increased the patient number with prediabetes and type 2 diabetes. In the CMD group, there were more frequent hospital complications. The Disse index was an independent predictor of long hospital stay and/or poor outcomes.