Surgical damage stimulates proliferation of dopamine uptake sites in normal mouse brain

• Published in: Brain research Vol. 622; no. 1-2; p. 285
• Main Authors: Howells, D W, Donnan, G A, Wong, J Y, Kaczmarczyk, S J, Chilcho, P J, Fabinyi, G C, Mendelsohn, F A
• Format: Journal Article
• Language: English
• Published: Netherlands 17-09-1993
• Subjects: Adrenal Medulla - transplantation; Animals; Brain - metabolism; Cerebral Cortex - transplantation; Corpus Striatum - surgery; Dopamine - metabolism; Gelatin Sponge, Absorbable; Male; Mice; Mice, Inbred C57BL; Reference Values; Transplantation, Heterotopic - adverse effects
• ISSN: 0006-8993
• DOI: 10.1016/0006-8993(93)90830-G

To test the hypothesis that proliferation of host dopaminergic tissue in response to injury plays an important role in the response to intrastriatal grafting, we transplanted autologous adrenal medullary to striatum in normal C57-black mice and compared this procedure with transplantation of non-dopaminergic tissue (frontal cortex) or a non-cellular matrix (Gelfoam). [3H]Mazindol autoradiography revealed that all three protocols resulted in a marked proliferation of dopamine uptake sites 10 months after transplantation.