PINK1 and Parkin: The odd couple

• Published in: Neuroscience research Vol. 159; pp. 25 - 33
• Main Authors: Yoboue, Edgar Djaha, Valente, Enza Maria
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01-10-2020
• Subjects: Humans; MAMs; Mitochondria; Mitochondria - enzymology; Mitochondria - genetics; Mitophagy; Mitophagy - genetics; Parkin; Parkinson; Parkinson Disease - enzymology; Parkinson Disease - genetics; Parkinson Disease - physiopathology; PINK1; Protein Kinases - metabolism; Ubiquitin; Ubiquitin-Protein Ligases - metabolism; Ubiquitin; PINK1; Mitochondria; MAMs; Mitophagy; Parkinson; Parkin
• ISSN: 0168-0102; 1872-8111
• DOI: 10.1016/j.neures.2020.04.007

•PINK1, Parkin and ubiquitin act closely together in regulation of mitophagy.•PINK1 has emerged as a new actor at the mitochondria-ER contact sites.•PINK1 and Parkin connections encompass mitophagy.•Crystal structures of PINK1 shed light on its features and impact of mutations.
In 2004, PINK1 was established as a gene linked to early onset of autosomal recessive juvenile Parkinsonism. Since then, tremendous efforts allowed involving the gene product in diverse events but with a strong focus on its partnership with the protein Parkin for the degradation of damaged mitochondria through mitophagy. Yet, it is now clear that the importance of PINK1 encompasses a wider spectrum of intracellular processes. In this minireview, we highlight some of the PINK1 interplays and recent advances, including its growing involvement in immunity and also its emerging place in this era of mitochondria-organelles contact sites.