Unbalanced 6p translocation as primary karyotypic anomaly in secondary acute nonlymphocytic leukemia

A case of acute nonlymphocytic leukemia after radiochemotherapy for Hodgkin's disease, with a rearrangement of 6p23 region, is described. This chromosome change, which has been previously reported in secondary leukemias or myelodysplastic syndromes, was an isolated karyotypic anomaly in our cas...

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Bibliographic Details
Published in:	Cancer genetics and cytogenetics Vol. 60; no. 1; p. 93
Main Authors:	Mancini, M, Mecucci, C, Cedrone, M, Rondinelli, M B, Aloe-Spiriti, M A, Alimena, G
Format:	Journal Article
Language:	English
Published:	United States 01-05-1992
Subjects:	Adult Antineoplastic Combined Chemotherapy Protocols - adverse effects Chromosomes, Human, Pair 6 Female Hodgkin Disease - drug therapy Hodgkin Disease - radiotherapy Humans Karyotyping Leukemia, Myeloid, Acute - chemically induced Leukemia, Myeloid, Acute - etiology Leukemia, Myeloid, Acute - genetics Leukemia, Radiation-Induced - genetics Translocation, Genetic
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Summary:	A case of acute nonlymphocytic leukemia after radiochemotherapy for Hodgkin's disease, with a rearrangement of 6p23 region, is described. This chromosome change, which has been previously reported in secondary leukemias or myelodysplastic syndromes, was an isolated karyotypic anomaly in our case, which strongly supports the nonrandom involvement of chromosome 6p in induced leukemias.
ISSN:	0165-4608
DOI:	10.1016/0165-4608(92)90242-Z