Effect of polar-planar compounds on the differentiation of normal human myeloid immature marrow cells

Polar-planar compounds which are potent differentiating agents, have been reported to enhance the response of friend erythroleukaemic cells and other malignant cell lines to mitomycin C, cis-platinum and radiation. With the upcoming of phase II clinical trials of these polar compounds alone and in c...

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Bibliographic Details
Published in:	Cancer letters Vol. 46; no. 1; p. 37
Main Authors:	Hassan, H T, Rees, J K
Format:	Journal Article
Language:	English
Published:	Ireland 01-07-1989
Subjects:	Acetamides - pharmacology Cell Differentiation - drug effects Cell Line Cell Survival - drug effects Dimethyl Sulfoxide - pharmacology Dimethylformamide - pharmacology Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Humans Structure-Activity Relationship Tetrazolium Salts
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Summary:	Polar-planar compounds which are potent differentiating agents, have been reported to enhance the response of friend erythroleukaemic cells and other malignant cell lines to mitomycin C, cis-platinum and radiation. With the upcoming of phase II clinical trials of these polar compounds alone and in combination with cytotoxic agents, the effect of 3 polar compounds: dimethylsulphoxide, dimethylformamide and hexamethylene bisacetamide on the differentiation of normal human myeloid immature marrow cells was studied. The results showed that a long-term exposure to these polar compounds may lead to a premature senescence of these marrow progenitors.
ISSN:	0304-3835
DOI:	10.1016/0304-3835(89)90212-7