Clinical and laboratory characteristics of central nervous system herpes simplex virus infection in neonates and young infants

We reviewed the characteristics of infants <3 months of age with central nervous system herpes simplex virus infection at our institution. Twenty-six cases were identified. The age range was 4-73 days. Most infants presented with fever, seizure activity and skin lesions. The blood herpes simplex...

Full description

Saved in:

Bibliographic Details
Published in:	The Pediatric infectious disease journal Vol. 33; no. 11; pp. 1187 - 1189
Main Authors:	Kotzbauer, David, Andresen, Deborah, Doelling, Nancy, Shore, Steve
Format:	Journal Article
Language:	English
Published:	United States 01-11-2014
Subjects:	Acyclovir - therapeutic use Antiviral Agents - therapeutic use Cerebrospinal Fluid - virology Fever - virology Herpes Simplex - blood Herpes Simplex - complications Herpes Simplex - drug therapy Humans Infant Infant, Newborn Magnetic Resonance Imaging Meningoencephalitis - blood Meningoencephalitis - drug therapy Meningoencephalitis - virology Retrospective Studies Seizures - virology Skin Diseases, Viral - virology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	We reviewed the characteristics of infants <3 months of age with central nervous system herpes simplex virus infection at our institution. Twenty-six cases were identified. The age range was 4-73 days. Most infants presented with fever, seizure activity and skin lesions. The blood herpes simplex virus polymerase chain reaction was positive in 91% of patients tested. Suppressive oral acyclovir therapy was likely helpful in preventing disease recurrence.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0891-3668 1532-0987
DOI:	10.1097/INF.0000000000000433