Triterpenoid saponins from the stem barks of Chytranthus klaineanus Radlk. ex Engl

• Published in: Phytochemistry letters Vol. 37; pp. 37 - 41
• Main Authors: Biang, Armand Emmanuel Moffi, Kamto, Eutrophe Le Doux, Simo, Line Made, Antheaume, Cyril, Lavedan, Pierre, Vedrenne, Marc, Noté, Olivier Placide, Pegnyemb, Dieudonné Emmanuel, Mbing, Joséphine Ngo, Haddad, Mohamed
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01-06-2020
• Subjects: Chemical Sciences; Chytranthus klaineanus; Klaineanosides; NMR; Sapindaceae; Triterpenoid saponins; Klaineanosides; NMR; Chytranthus klaineanus; Triterpenoid saponins; Sapindaceae
• ISSN: 1874-3900; 1876-7486
• DOI: 10.1016/j.phytol.2020.04.006

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•Three new triterpenoid saponins, named Klaineanosides A–C were isolated from the stem of Chytranthus klaineanus.•Their structures were established on the basis of extensive analysis of 1D and 2D NMR experiments.•The three saponins have a -3Rha-2Ara-3hederagenin sequence usually found in Sapindaceae.
In our continuing studies on saponins from Cameroonian medicinal plants, phytochemical investigation of Chytranthus klaineanus stem barks led to the isolation of three new oleanane-type saponins, named Klaineanosides A–C (1–3). Their structures were established by extensive analysis of their spectral data, mainly 1D (1H, 13C NMR, and DEPT) and 2D (COSY, HSQC, NOESY, HSQC-TOCSY, and HMBC) NMR experiments, and mass spectrometry as 3-O-β-d-glucopyranosyl-(1→3)-β-d-xylopyranosyl-(1→4)[-β-d-xylopyranosyl(1→3)-β-d-xylopyranosyl(1→3)-α-l-rhamnopyranosyl-(1→2)]-α-l-arabinopyranosylhederagenin (1), 3-O-β-d-glucopyranosyl-(1→3)-β-d-xylopyranosyl-(1→4)[β-d-xylopyranosyl(1→3)-α-l-rhamnopyranosyl-(1→2)]-α-l-arabinopyranosylhederagenin (2), and 3-O-β-d-xylopyranosyl(1→4)-β-d-glucopyranosyl-(1→3)-α-l-rhamnopyranosyl-(1→2)-α-l-arabinopyranosylhederagenin (3). These triterpene saponins 1–3 have hederagenin as aglycone with a -3Rha-2Ara-3hederagenin oligosaccharidic sequence usually found in Sapindaceae family.