The Effect of Quercus coccifera L. Extract on the Necrosis of Random-pattern Skin Flaps in Rats
Aim: Ischemia-reperfusion injury is an important cause of flap loss. We investigated effects of Quercus coccifera L. extract known to have anti-oxidant and anti-inflammatory activity on skin flap viability. Methods: Eighteen Wistar rats were used. Random-pattern skin flaps, 9x3 cm in size, were appl...
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| Published in: | Haseki tıp bülteni Vol. 57; no. 3; pp. 249 - 254 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
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Istanbul
Haseki Eğitim ve Araştırma Hastanesi
01-09-2019
Galenos Publishing House Galenos Yayinevi |
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| Abstract | Aim: Ischemia-reperfusion injury is an important cause of flap loss. We investigated effects of Quercus coccifera L. extract known to have anti-oxidant and anti-inflammatory activity on skin flap viability.
Methods: Eighteen Wistar rats were used. Random-pattern skin flaps, 9x3 cm in size, were applied on rats back and then the rats were divided into three groups. Following surgery, 2 cc of nitrofurazone cream and 2 cc of Q. coccifera L. water extract were applied daily in groups 2 and 3, respectively. Group 1 received no treatment after surgery. The percentage of necrosis on the flaps was calculated and histopathological examination of the tissue samples was made on day 7.
Results: The mean percentage of necrosis was 44.7%, 42.5% and 21.8% group 1, 2 and 3, respectively. The percentage of necrosis was statistically significantly lower in group 3 than in groups 1 and 2 (p<0.001 and p<0.00, respectively). Neutrophil score was found to be significantly lower in group 3 than in groups 1 and 2 (p=0.002 and p=0.002, respectively).
Conclusions: Necrosis of skin flaps was decreased through application of Q. coccifera extracts |
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| AbstractList | Aim: Ischemia-reperfusion injury is an important cause of flap loss. We investigated effects of Quercus coccifera L. extract known to have anti-oxidant and anti-inflammatory activity on skin flap viability.
Methods: Eighteen Wistar rats were used. Random-pattern skin flaps, 9x3 cm in size, were applied on rats back and then the rats were divided into three groups. Following surgery, 2 cc of nitrofurazone cream and 2 cc of Q. coccifera L. water extract were applied daily in groups 2 and 3, respectively. Group 1 received no treatment after surgery. The percentage of necrosis on the flaps was calculated and histopathological examination of the tissue samples was made on day 7.
Results: The mean percentage of necrosis was 44.7%, 42.5% and 21.8% group 1, 2 and 3, respectively. The percentage of necrosis was statistically significantly lower in group 3 than in groups 1 and 2 (p<0.001 and p<0.00, respectively). Neutrophil score was found to be significantly lower in group 3 than in groups 1 and 2 (p=0.002 and p=0.002, respectively).
Conclusions: Necrosis of skin flaps was decreased through application of Q. coccifera extracts Aim: Ischemia-reperfusion injury is an important cause of flap loss. We investigated effects of Quercus coccifera L. extract known to have anti-oxidant and anti-inflammatory activity on skin flap viability. Methods: Eighteen Wistar rats were used. Random-pattern skin flaps, 9x3 cm in size, were applied on rats back and then the rats were divided into three groups. Following surgery, 2 cc of nitrofurazone cream and 2 cc of Q. coccifera L. water extract were applied daily in groups 2 and 3, respectively. Group 1 received no treatment after surgery. The percentage of necrosis on the flaps was calculated and histopathological examination of the tissue samples was made on day 7. Results: The mean percentage of necrosis was 44.7%, 42.5% and 21.8% group 1, 2 and 3, respectively. The percentage of necrosis was statistically significantly lower in group 3 than in groups 1 and 2 (p<0.001 and p<0.00, respectively). Neutrophil score was found to be significantly lower in group 3 than in groups 1 and 2 (p=0.002 and p=0.002, respectively). Conclusions: Necrosis of skin flaps was decreased through application of Q. coccifera extracts. |
| Abstract_FL | Amaç: İskemi-reperfüzyon hasarı önemli bir flep kaybı nedenidir. Bu çalışmada antioksidan ve antiinflamatuvar aktivitesi olduğu bilinen Quercus coccifera ekstresinin flep yaşayabilirliği üzerindeki etkisi incelenmiştir
Yöntemler: On sekiz Wistar cinsi sıçan kullanıldı. Sıçanların sırt bölgesinde 9x3 cm’lik random patern deri flebi kaldırıldı ve daha sonra flep tekrar aynı yere iade edildi. Daha sonra ratlar üç gruba ayrıldı. Grup 2’deki sıçanların sırtlarına günde bir defa 2 cc nitrofurazon krem, grup 3’teki sıçanların sırtına ise günde bir defa 2 cc Q. coccifera ektresi uygulandı. Grup 1’deki sıçanlara flep cerrahisi dışında bir işlem yapılmadı. Flep cerrahisinden 7 gün sonra fleplerdeki nekroz miktarı hesaplandı ve doku örnekleri alınarak histopatolojik inceleme yapıldı
Bulgular: Grup 1’de ortalama nekroz miktarı %44,1, grup 2’de %42,5 ve grup 3’de %21,8 olarak hesaplandı. Grup 3’deki nekroz miktarı, grup 1 ve grup 2’den istatistiksel olarak anlamlı olacak şekilde az olduğu tespit edildi (p<0,001, p<0,001). Nötrofil skoru da grup 3 ‘de, grup 1 ve grup 2’ye göre istatistiksel olarak anlamlı olacak şekilde az bulundu. (p=0,002 ve p=0,002)
Sonuç: Q. coccifera ekstresi uygulanması ile fleplerdeki nekroz miktarı azalmaktadır. |
| Author | Orhan, Erkan Kuruüzüm Uz, Ayşe Bilensoy, Erem Yüzbaşıoğlu, Merve Yavuz, Burçin Özkaya Aka, İlsun |
| AuthorAffiliation | Genel Cerrahi Kliniği Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Anabilim Dalı Cerrahi Tıp Bilimleri Bölümü, Plastik ve Rekonstrüktif Cerrahi Anabilim Dalı Eczacılık Teknolojisi Bölümü, Farmasotik Teknoloji Anabilim Dalı |
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| SubjectTerms | Antioxidants Ischemia Metabolites Necrosis Quercus coccifera L Sağlık Hizmetleri skin flap Studies Surgery Tıp |
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| Title | The Effect of Quercus coccifera L. Extract on the Necrosis of Random-pattern Skin Flaps in Rats |
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