The Effect of Quercus coccifera L. Extract on the Necrosis of Random-pattern Skin Flaps in Rats

• Published in: Haseki tıp bülteni Vol. 57; no. 3; pp. 249 - 254
• Main Authors: Orhan, Erkan, Özkaya Aka, İlsun, Yüzbaşıoğlu, Merve, Yavuz, Burçin, Bilensoy, Erem, Kuruüzüm Uz, Ayşe
• Format: Journal Article
• Language: English
• Published: Istanbul Haseki Eğitim ve Araştırma Hastanesi 01-09-2019; Galenos Publishing House; Galenos Yayinevi
• Subjects: Antioxidants; Ischemia; Metabolites; Necrosis; Quercus coccifera L; Sağlık Hizmetleri; skin flap; Studies; Surgery; Tıp; İstanbul; Türkiye; Ankara Turkey; Anatolia; Turkey; deri flebi; skin flap; Quercus coccifera L; necrosis; nekroz
• ISSN: 1302-0072; 2147-2688
• DOI: 10.4274/haseki.galenos.2018.4533

Aim: Ischemia-reperfusion injury is an important cause of flap loss. We investigated effects of Quercus coccifera L. extract known to have anti-oxidant and anti-inflammatory activity on skin flap viability.
Methods: Eighteen Wistar rats were used. Random-pattern skin flaps, 9x3 cm in size, were applied on rats back and then the rats were divided into three groups. Following surgery, 2 cc of nitrofurazone cream and 2 cc of Q. coccifera L. water extract were applied daily in groups 2 and 3, respectively. Group 1 received no treatment after surgery. The percentage of necrosis on the flaps was calculated and histopathological examination of the tissue samples was made on day 7.
Results: The mean percentage of necrosis was 44.7%, 42.5% and 21.8% group 1, 2 and 3, respectively. The percentage of necrosis was statistically significantly lower in group 3 than in groups 1 and 2 (p<0.001 and p<0.00, respectively). Neutrophil score was found to be significantly lower in group 3 than in groups 1 and 2 (p=0.002 and p=0.002, respectively).
Conclusions: Necrosis of skin flaps was decreased through application of Q. coccifera extracts