Vaccination of mice against Leishmania mexicana amazonensis with microsomal fraction associated with BCG

Vaccination of mice against Leishmania mexicana amazonensis with microsomal fraction associated with BCG

Attempts to develop a satisfactory vaccine against New World cutaneous leishmaniasis have been made with varying success. We found that in mice, pretreated subcutaneously with 2 X 10(6) BCG organisms 2 weeks prior to immunization at the same site with as low as 10 micrograms of a microsomal preparat...

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Bibliographic Details
Published in:Annales de l'Institut Pasteur. Immunology Vol. 139; no. 2; p. 143
Main Authors: Goncalves da Costa, S, Santos, E B, Lagrange, P H
Format: Journal Article
Language:English
Published: Netherlands 01-03-1988
Subjects:
Animals
BCG Vaccine - immunology
Female
Hypersensitivity, Delayed
Immunization, Passive
Leishmania mexicana - immunology
Male
Mice
Mice, Inbred C57BL
Microsomes - immunology
Skin - pathology
Vaccination
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Summary:Attempts to develop a satisfactory vaccine against New World cutaneous leishmaniasis have been made with varying success. We found that in mice, pretreated subcutaneously with 2 X 10(6) BCG organisms 2 weeks prior to immunization at the same site with as low as 10 micrograms of a microsomal preparation (Pol-F) of Leishmania mexicana amazonensis, a profound alteration was observed in the course of infection produced by inoculation of virulent amastigotes of the same strain. The BCG-Pol-F vaccine preparation was consistently shown to have a protective capacity associated with larger classical cellular immune response (skin test) and higher specific antibody titres in response to leishmanial challenge dose (1 X 10(6) amastigotes/mouse).
ISSN:0769-2625
DOI:10.1016/0769-2625(88)90036-0