GABA and phospholipids in penicillin-induced seizures

• Published in: Experimental neurology Vol. 90; no. 1; p. 278
• Main Authors: Loeb, C, Bo, G P, Scotto, P A, Benassi, E, Besio, G, Mainardi, P, Faverio, A
• Format: Journal Article
• Language: English
• Published: United States 01-10-1985
• Subjects: Action Potentials - drug effects; Animals; Brain - drug effects; gamma-Aminobutyric Acid - pharmacology; Male; Penicillins; Phosphatidylcholines - pharmacology; Phosphatidylethanolamines - pharmacology; Phosphatidylserines - pharmacology; Phospholipids - pharmacology; Rats; Rats, Inbred Strains; Seizures - chemically induced
• ISSN: 0014-4886
• DOI: 10.1016/0014-4886(85)90062-7

The effect of a suspension of GABA and phosphatidylserine (PS), phosphatidylcholine, or phosphatidylethanolamine was studied on penicillin-induced epileptic activity in rats. GABA-PS significantly reduced the number of spikes, in comparison with either the other phospholipid compounds or normal saline. No effect was observed after GABA or PS administration alone. We suggest that the different effects probably depend on extracellular and intracellular factors.