Methylphenidate increases thought disorder in recent onset schizophrenics, but not in normal controls

The effects of apomorphine and methylphenidate on thought disorder, as measured by the Thought Disorder Index, in schizophrenic patients and in normal controls were evaluated. Methylphenidate, but not apomorphine, increased thought disorder in patients. Neither drug significantly increased thought d...

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Bibliographic Details
Published in:	Biological psychiatry (1969) Vol. 34; no. 8; p. 507
Main Authors:	Levy, D L, Smith, M, Robinson, D, Jody, D, Lerner, G, Alvir, J, Geisler, S H, Szymanski, S R, Gonzalez, A, Mayerhoff, D I
Format:	Journal Article
Language:	English
Published:	United States 15-10-1993
Subjects:	Adult Apomorphine - pharmacology Brain - drug effects Brain - physiopathology Dopamine - physiology Female Humans Male Methylphenidate - pharmacology Psychiatric Status Rating Scales Schizophrenia - physiopathology Schizophrenic Psychology Synaptic Transmission - drug effects Synaptic Transmission - physiology Thinking - drug effects Thinking - physiology
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Summary:	The effects of apomorphine and methylphenidate on thought disorder, as measured by the Thought Disorder Index, in schizophrenic patients and in normal controls were evaluated. Methylphenidate, but not apomorphine, increased thought disorder in patients. Neither drug significantly increased thought disorder in controls.
ISSN:	0006-3223
DOI:	10.1016/0006-3223(93)90192-G