Oleanane-type triterpene saponins and cassaine-type diterpenoids from Erythrophleum fordii

• Published in: Planta medica Vol. 77; no. 14; p. 1631
• Main Authors: Du, Dan, Fang, Lei, Qu, Jing, Yu, Shishan, Ma, Shuanggang, Lv, Haining, Liu, Jing, Liu, Yuanyan, Wang, Jiaming, Wang, Xiaojing
• Format: Journal Article
• Language: English
• Published: Germany 01-09-2011
• Subjects: Alkaloids - chemistry; Alkaloids - isolation & purification; Alkaloids - pharmacology; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Cell Line, Tumor; Cell Survival; Diterpenes - chemistry; Diterpenes - isolation & purification; Diterpenes - pharmacology; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal - chemistry; Fabaceae - chemistry; Female; Glycosides - chemistry; Glycosides - isolation & purification; Glycosides - pharmacology; Humans; Magnetic Resonance Spectroscopy; Medicine, Chinese Traditional; Molecular Structure; Oleanolic Acid - chemistry; Oleanolic Acid - isolation & purification; Oleanolic Acid - pharmacology; Plant Leaves - chemistry; Plants, Medicinal - chemistry; Saponins - chemistry; Saponins - isolation & purification; Saponins - pharmacology
• ISSN: 1439-0221
• DOI: 10.1055/s-0030-1270992

Phytochemical investigation of the EtOH extract of the leaves of Erythrophleum fordii led to the isolation of two oleanane-type triterpene saponins (1-2) and five cassaine-type diterpenoids (4-8) along with one known methyl 3 β-hydroxy-erythrosuamate (3). Their structures were established by extensive NMR, as well as ESI-MS analyses and acid hydrolysis. Biological evaluation of compounds 3- 8 against five human cancer cell lines revealed that compounds 5-7 exhibited potent cytotoxic activity with IC₅₀ values ranging from 1.51 to 8.68 µM.