Podacycline A and B, two cyclic peptides in the latex of Jatropha podagrica

• Published in: Phytochemistry (Oxford) Vol. 42; no. 1; pp. 129 - 133
• Main Authors: Van den Berg, Albert J.J., Horsten, Stephan F.A.J., Jantina Kettenes-van den Bosch, J., Beukelman, Cees J., Kroes, Burt H., Leeflang, Bas R., Labadie, Rudi P.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01-05-1996; Elsevier
• Subjects: Amino Acid Sequence; Amino Acids - analysis; Biological and medical sciences; Biotechnology; Chemical constitution; Chromatography, Ion Exchange; Fundamental and applied biological sciences. Psychology; Latex - chemistry; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Peptides, Cyclic - chemistry; Peptides, Cyclic - isolation & purification; Plant physiology and development; Spectrometry, Mass, Fast Atom Bombardment; cyclic peptides; podacycline B; podacycline A; Euphorbiaceae; Jatropha podagrica; Molecular structure; Cyclic peptides; Dicotyledones; Angiospermae; Absolute configuration; Isolation; Spermatophyta; Latex
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/0031-9422(95)00912-4

Two novel cyclic peptides were isolated from the latex of
Jatropha podagrica, which we named podacycline A and B. Podacycline A is a cyclic nonapeptide with the sequence Gly1-Leu2-Leu3-Gly4-Ala5-Val6-Trp7-Ala8-Gly9-Gly1. The sequence of podacycline B, a cyclic heptapeptide, was determined to be Phe1-Ala2-Gly-3-Thr4-Ile5-Phe6-Gly7-Phe1. The amino acid residues of both compounds were found to have the
l-configuration.