Induction of xanthine oxidase and depression of cytochrome P-450 by interferon inducers: genetic difference in the responses of mice

• Published in: Biochemical and biophysical research communications Vol. 131; no. 1; p. 109
• Main Authors: Deloria, L, Abbott, V, Gooderham, N, Mannering, G J
• Format: Journal Article
• Language: English
• Published: United States 30-08-1985
• Subjects: Animals; Cytochrome P-450 Enzyme Inhibitors; Enzyme Induction - drug effects; Ethylmorphine-N-Demethylase - antagonists & inhibitors; Interferons - blood; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Microsomes, Liver - drug effects; Microsomes, Liver - enzymology; Poly I-C - pharmacology; Species Specificity; Xanthine Oxidase - biosynthesis
• ISSN: 0006-291X
• DOI: 10.1016/0006-291X(85)91777-2

Interferon and interferon inducing agents depress hepatic cytochrome P-450 systems. They also induce hepatic xanthine oxidase activity. It has been suggested that free radicals produced by xanthine oxidase may cause the loss of P-450. High titers of serum interferon are induced by poly IC (poly riboinosinic acid.polyribocytidylic acid) in both C57Bl/6J and C3H/HeJ mice; Newcastle disease virus (NDV) induces a high titer of interferon in C57Bl/6J mice but not in C3H/HeJ mice. The induction of xanthine oxidase activity by NDV in C3H/HeJ mice was less than half that seen in C57Bl/6J mice, thus demonstrating a relationship between the induction of xanthine oxidase, the depression of P-450 and a genetically determined difference in responsiveness of mice to interferon inducers.