The sensitivity of human tumour cells to quinone bioreductive drugs: what role for DT-diaphorase?

15 human tumour cell lines (lung, breast and colon) have been evaluated for their sensitivity to the quinone based anti-cancer drugs Mitomycin C, Porfiromycin, and EO9 (3-hydroxymethyl-5-aziridinyl-1-methyl-2-(IH-indole-4,7-dione)prop-beta- en-alpha-ol). Sensitivity has been compared with the intra-...

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Bibliographic Details
Published in:	Biochemical pharmacology Vol. 44; no. 3; p. 409
Main Authors:	Robertson, N, Stratford, I J, Houlbrook, S, Carmichael, J, Adams, G E
Format:	Journal Article
Language:	English
Published:	England 04-08-1992
Subjects:	Antineoplastic Agents - pharmacology Aziridines - pharmacology Dihydrolipoamide Dehydrogenase - analysis Humans Indolequinones Indoles - pharmacology Mitomycin - pharmacology Oxidation-Reduction Porfiromycin - pharmacology Quinones - pharmacology Tumor Cells, Cultured - drug effects
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Summary:	15 human tumour cell lines (lung, breast and colon) have been evaluated for their sensitivity to the quinone based anti-cancer drugs Mitomycin C, Porfiromycin, and EO9 (3-hydroxymethyl-5-aziridinyl-1-methyl-2-(IH-indole-4,7-dione)prop-beta- en-alpha-ol). Sensitivity has been compared with the intra-cellular levels of DT-diaphorase, an enzyme thought to be important in the reductive activation of these quinones. No correlation exists between levels of DT-diaphorase and sensitivity to Mitomycin C or Porfiromycin. However, for EO9 those cell lines showing highest levels of DT-diaphorase activity tend to be the most sensitive.
ISSN:	0006-2952
DOI:	10.1016/0006-2952(92)90429-M