A multifunctional phosphorescent iridium(III) complex for specific nucleus staining and hypoxia monitoring

A multifunctional phosphorescent iridium(III) complex (Ir1) for specific nucleus staining was synthesized and applied for monitoring the intranuclear oxygen level. With the advantageous long emission lifetime of Ir1, the influence of autofluorescence could be eliminated by using photoluminescence li...

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Bibliographic Details
Published in:	Chemical communications (Cambridge, England) Vol. 51; no. 37; p. 7943
Main Authors:	Liu, Shujuan, Liang, Hua, Zhang, Kenneth Yin, Zhao, Qiang, Zhou, Xiaobo, Xu, Wenjuan, Huang, Wei
Format:	Journal Article
Language:	English
Published:	England 07-05-2015
Subjects:	Cell Nucleus - chemistry HeLa Cells Hep G2 Cells Humans Hypoxia - diagnosis Iridium - chemistry Luminescence Luminescent Agents - chemical synthesis Luminescent Agents - chemistry Luminescent Measurements MCF-7 Cells Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Oxygen - analysis Staining and Labeling - methods
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Summary:	A multifunctional phosphorescent iridium(III) complex (Ir1) for specific nucleus staining was synthesized and applied for monitoring the intranuclear oxygen level. With the advantageous long emission lifetime of Ir1, the influence of autofluorescence could be eliminated by using photoluminescence lifetime imaging and time-gated luminescence imaging techniques.
ISSN:	1364-548X
DOI:	10.1039/c5cc01978h