Antitumor and cytotoxic screen of 5,6,7-trisubstituted flavones from Gomphrena martiana

• Published in: Journal of ethnopharmacology Vol. 44; no. 1; p. 25
• Main Authors: Pomilio, A B, Solá, G A, Mayer, A M, Rumi, L S
• Format: Journal Article
• Language: English
• Published: Ireland 01-08-1994
• Subjects: Animals; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Carcinoma, Ehrlich Tumor - drug therapy; Drug Screening Assays, Antitumor; Female; Flavonoids - isolation & purification; Flavonoids - pharmacology; Male; Mice; Mice, Inbred BALB C; Plants, Medicinal; Sarcoma 180 - drug therapy; Tumor Cells, Cultured
• ISSN: 0378-8741
• DOI: 10.1016/0378-8741(94)90095-7

An in vivo antitumor screening of extracts of Gomphrena martiana indicated positive activity in the petroleum ether extract, and its further bioactivity-directed fractionation resulted in a lipophilic flavonoid fraction. Upon inoculation of various doses of 5,6,7-trisubstituted flavones on two murine tumor lines, Sarcoma 180 and Ehrlich's carcinoma, a decrease of tumor growth was observed. An in vitro KB cultured cell screen indicated cytotoxicity.