Ceftriaxone treatment of multidrug-resistant Salmonella osteomyelitis

• Published in: The American journal of medicine Vol. 83; no. 1; p. 137
• Main Authors: Sherman, J W, Conte, Jr, J E
• Format: Journal Article
• Language: English
• Published: United States 01-07-1987
• Subjects: Adult; Ceftriaxone - therapeutic use; Drug Resistance, Microbial; Equipment Contamination; Hip Prosthesis; Humans; Male; Microbial Sensitivity Tests; Osteomyelitis - drug therapy; Osteomyelitis - microbiology; Prosthesis Failure; Salmonella - drug effects; Salmonella - isolation & purification; Salmonella Infections - drug therapy; Salmonella Infections - microbiology
• ISSN: 0002-9343
• DOI: 10.1016/0002-9343(87)90508-0

Empiric treatment of serious Salmonella infections has been complicated by the emergence of strains resistant to multiple antimicrobial agents, including ampicillin, chloramphenicol, and trimethoprim/sulfamethoxazole. Recent reports suggest that the third-generation cephalosporins may be effective therapy for Salmonella infections. This report describes a case of antibiotic-resistant Salmonella heidelberg prosthetic hip infection successfully treated with prosthesis removal and once-daily ceftriaxone. Tube dilution sensitivity testing of the organism demonstrated minimal inhibitory and minimal bactericidal concentrations of 0.12 microgram/ml. Serum bactericidal activity, 30 minutes after infusion, was inhibitory and bactericidal at 1:512. It is concluded that the favorable preliminary results reported in the literature and the outcome in this patient suggest that the third-generation cephalosporins may be effective therapy for Salmonella infections and should undergo clinical trials.