Poloxalene 2930, a hydrophobic surfactant that prevents atherosclerosis, alters composition of rabbit lipoproteins

• Published in: Atherosclerosis Vol. 57; no. 2-3; p. 149
• Main Authors: Kapuscinska, B, Bochenek, W J, Peng, S K, Rodgers, J B
• Format: Journal Article
• Language: English
• Published: Ireland 01-11-1985
• Subjects: Animals; Apolipoproteins B - blood; Apolipoproteins E - blood; Arteriosclerosis - prevention & control; Blood Proteins - metabolism; Cholesterol - blood; Cholesterol, LDL - blood; Cholesterol, VLDL; Diet, Atherogenic; Lipoproteins - blood; Lipoproteins, VLDL - blood; Male; Poloxalene - pharmacology; Polyethylene Glycols - pharmacology; Rabbits; Triglycerides - blood
• ISSN: 0021-9150
• DOI: 10.1016/0021-9150(85)90028-0

Poloxalene 2930, a hydrophobic surfactant, was incorporated into an atherogenic diet at dose levels, 0.5% and 1% of the diet, and fed to rabbits for 10 weeks. Another group received plain atherogenic diet alone and a control group was fed chow. After this period, serum lipoproteins were separated by centrifugation and analyzed. The composition of lipoproteins from rabbits on atherogenic diet was abnormal. The cholesterol: triglyceride ratio of every lipoprotein fraction was significantly increased as was the cholesterol: protein ratio of very low density lipoproteins. Supplementing the diet with Poloxalene 2930 prevented these alterations. In all groups on the atherogenic diet the percentage of apolipoprotein E in VLDL and HDL increased. In the case of Poloxalene-treated rabbits this developed even though serum cholesterol levels were normal or slightly increased. It is concluded that Poloxalene 2930 has a systemic effect on lipoproteins which may contribute to its antiatherogenic action.