Pseudo-Cushing's syndrome: an example of alcohol-induced central disorder in corticotropin-releasing factor-ACTH release?

Six chronic alcoholics with stigmata of Cushing's syndrome were studied before and after a period of alcohol abstinence. In all of them, after a minimum period of 3-4 weeks, a marked clinical and laboratory improvement was noted. The authors suggest that damage at brain level, with neurotransmi...

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Bibliographic Details
Published in:	Drug and alcohol dependence Vol. 16; no. 2; p. 111
Main Authors:	Proto, G, Barberi, M, Bertolissi, F
Format:	Journal Article
Language:	English
Published:	Ireland 01-11-1985
Subjects:	11-Hydroxycorticosteroids - urine 17-Ketosteroids - urine Adolescent Adrenocorticotropic Hormone - blood Adult Alcoholism - blood Corticotropin-Releasing Hormone - blood Cushing Syndrome - blood Dexamethasone Female Humans Hydrocortisone - blood Male Radioimmunoassay
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Summary:	Six chronic alcoholics with stigmata of Cushing's syndrome were studied before and after a period of alcohol abstinence. In all of them, after a minimum period of 3-4 weeks, a marked clinical and laboratory improvement was noted. The authors suggest that damage at brain level, with neurotransmitters' disturbance, caused by chronic alcoholism underlies the Pseudo-Cushing's Syndrome. The primum movens could be a disorder of the pituitary-adrenal axis secondary to a dysfunction of neurotransmitters with stimulation of ACTH-secreting cells of the adenohypophysis by the certicotropin-releasing factor (CRF).
ISSN:	0376-8716
DOI:	10.1016/0376-8716(85)90110-3