Effects of polyunsaturated fatty acids and of their oxidation products on cell survival

The stimulatory, cytostatic and cytotoxic effects of polyunsaturated fatty acids, prostaglandins, thromboxanes, hydroperoxy fatty acids, hydroxy fatty acids and leukotrienes on normal and tumor cells are described. Their effects are related to the ability of the cells to undergo lipid peroxidation....

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Bibliographic Details
Published in:	Chemistry and physics of lipids Vol. 45; no. 2-4; p. 269
Main Author:	Bégin, M E
Format:	Journal Article
Language:	English
Published:	Ireland 01-11-1987
Subjects:	Animals Cell Survival - drug effects Fatty Acids, Unsaturated - metabolism Fatty Acids, Unsaturated - pharmacology Humans Oxidation-Reduction
Online Access:	Get more information
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Summary:	The stimulatory, cytostatic and cytotoxic effects of polyunsaturated fatty acids, prostaglandins, thromboxanes, hydroperoxy fatty acids, hydroxy fatty acids and leukotrienes on normal and tumor cells are described. Their effects are related to the ability of the cells to undergo lipid peroxidation. The significance of controlled peroxidation of selected polyunsaturated fatty acids in the control of tumor development is examined. It is suggested that selected polyunsaturated fatty acids if used at appropriate concentrations may have a protective role against cancer development by inducing and/or mediating cytotoxic reactions in malignant cells directly or indirectly through the intermediacy of immune cells.
ISSN:	0009-3084
DOI:	10.1016/0009-3084(87)90069-7