Improved detection and derivatization in capillary electrophoresis

Improved detection and derivatization in capillary electrophoresis

Capillary electrophoresis is well known for its low mass detectabilities, but suffers from poor concentration detection limits. This review will discuss improvements in concentration detectability with an emphasis on derivatization methods. Sample concentration techniques and improved detector desig...

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Bibliographic Details
Published in:Journal of chromatography. A Vol. 659; no. 2; p. 231
Main Authors: Szulc, M E, Krull, I S
Format: Journal Article
Language:English
Published: Netherlands 28-01-1994
Subjects:
Amino Acids - analysis
Electrophoresis - methods
Oligosaccharides - analysis
Proteins - analysis
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Summary:Capillary electrophoresis is well known for its low mass detectabilities, but suffers from poor concentration detection limits. This review will discuss improvements in concentration detectability with an emphasis on derivatization methods. Sample concentration techniques and improved detector designs will also be discussed. Pre- and post-capillary derivatization methods for biofluid analytes such as amino acids, peptides, proteins, oligonucleotides, and oligosaccharides will be examined in detail.
ISSN:0021-9673
DOI:10.1016/0021-9673(94)85064-X