Low dose prophylaxis in Tunisian children with haemophilia

• Published in: Haemophilia : the official journal of the World Federation of Hemophilia Vol. 23; no. 1; pp. 77 - 81
• Main Authors: Gouider, E., Jouini, L., Achour, M., Elmahmoudi, H., Zahra, K., Saied, W., Meddeb, B.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01-01-2017
• Subjects: Adolescent; Bleeding; Child; Children; Female; functional independence score in haemophilia; haemophilia; haemophilia joint health score; Hemophilia; Hemophilia A - drug therapy; Humans; low dose prophylaxis; Male; Prophylaxis; Quality of life; Tunisia; haemophilia; functional independence score in haemophilia; prophylaxis; haemophilia joint health score; low dose prophylaxis
• ISSN: 1351-8216; 1365-2516
• DOI: 10.1111/hae.13048

Introduction
Low dose prophylaxis could be recommended in countries with limited resources.
Aim
We report our single centre experience in children with haemophilia.
Patients
Fifty‐five children were included in our study with a weekly median dose of 30 UI kg−1 given once, twice or thrice a week. Age of initiation of prophylaxis is 5.32 years (0.64–11.44). Outcome assessment used were number of bleeding before and after initiating prophylaxis, haemophilia joint health score (HJHS), functional independence score in haemophilia (FISH) and quality of life with the Haemo‐QoL.
Results
Reduction of number of bleeding was clear in all patients; HJHS, FISH and Haemo‐QOL were satisfactory.
Conclusion
Low dose prophylaxis is effective and better than on‐demand therapy. It should be the starting point for prophylaxis in countries with limited resources.