A pilot randomized, double-blind, placebo-controlled study of granisetron in the treatment of sexual dysfunction in women associated with antidepressant use

• Published in: International clinical psychopharmacology Vol. 19; no. 3; pp. 161 - 164
• Main Authors: Jespersen, Sean, Berk, Michael, Wyk, Caren Van, Dean, Olivia, Dodd, Seetal, Szabo, Christopher P, Maud, Catherine
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins, Inc 01-05-2004; Lippincott Williams & Wilkins
• Subjects: Adult; Antidepressive Agents - adverse effects; Biological and medical sciences; Double-Blind Method; Female; Fundamental and applied biological sciences. Psychology; Granisetron - therapeutic use; Humans; Medical sciences; Neuropharmacology; Pharmacology. Drug treatments; Pilot Projects; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Serotonin Antagonists - therapeutic use; Sexual Dysfunctions, Psychological - chemically induced; Sexual Dysfunctions, Psychological - drug therapy; Sexual Dysfunctions, Psychological - psychology; Surveys and Questionnaires; Human; Granisetron; sexual dysfunction; Serotonin antagonist; AISD; SSRI; Randomization; serotonin; 5-HT3 Serotonine receptor; Double blind study; Antidepressant agent; Female; Woman
• ISSN: 0268-1315; 1473-5857
• DOI: 10.1097/00004850-200405000-00007

A pilot study was conducted to evaluate the usefulness of granisetron for the treatment of antidepressant induced sexual dysfunction in women. Twelve women with antidepressant induced sexual dysfunction (AISD) were assigned granisetron (n=5) or placebo (n=7) in a 14-day randomized, double-blind, placebo-controlled study. One participant in the granisetron group did not complete the study. Participants were assessed at baseline, day 7 and day 14 using the Feiger Sexual Function and Satisfaction Questionnaire and the Arizona Sexual Experience Scale. No statistical differences were measured at baseline or at endpoint between the granisetron or placebo group. This study did not produce evidence supporting the usefulness of granisetron in AISD.