Pathogenetic aspects of severe course of herpetic infection

• Published in: Bulletin of experimental biology and medicine Vol. 144; no. 3; pp. 447 - 451
• Main Authors: Didkovskii, N A, Malashenkova, I K, Tanasova, A N, Zuikov, I A, Zuikova, I N, Khitrik, N M, Sarsaniya, Z S
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 01-09-2007
• Subjects: Anogenital; Comorbidity; Cytokines - blood; Cytokines - immunology; Female; Herpes simplex; Herpes simplex virus; Herpesviridae Infections - immunology; Herpesviridae Infections - physiopathology; Humans; Immunocompromised Host; Immunodeficiency; Immunoglobulins - metabolism; Immunologic Deficiency Syndromes - complications; Immunologic Deficiency Syndromes - immunology; Localization; Male; Simplexvirus - metabolism
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-007-0349-7

We studied the state of antiviral defense in patients with severe course of herpetic infection of anogenital and labial localization and the frequency of its combination with other herpes virus infections. It was found that severe course of herpetic infection caused by herpes simplex virus occurs against the background of combined secondary immunodeficiency and its complication. We first demonstrated that severe course of the disease is associated with mixed viral infection.