Bottom-up approach to build osteon-like structure by cell-laden photocrosslinkable hydrogel

Based on photocrosslinkable PEGDMA and GelMA hydrogels, two "bottom-up" approaches ("circle-and-cross" and "layer-by-layer") were successfully developed to construct osteon-like structures with microchannel networks. Significantly, the "layer-by-layer" approac...

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Bibliographic Details
Published in:	Chemical communications (Cambridge, England) Vol. 48; no. 26; p. 3170
Main Authors:	Zuo, Yicong, Xiao, Wenqian, Chen, Xiaoqin, Tang, Yajun, Luo, Hongrong, Fan, Hongsong
Format:	Journal Article
Language:	English
Published:	England 01-01-2012
Subjects:	Cell Line, Tumor Cell Survival Cross-Linking Reagents - chemical synthesis Cross-Linking Reagents - chemistry Gelatin - chemical synthesis Gelatin - chemistry Human Umbilical Vein Endothelial Cells - cytology Humans Hydrogels - chemical synthesis Hydrogels - chemistry Methacrylates - chemical synthesis Methacrylates - chemistry Photochemical Processes Polyethylene Glycols - chemical synthesis Polyethylene Glycols - chemistry
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Summary:	Based on photocrosslinkable PEGDMA and GelMA hydrogels, two "bottom-up" approaches ("circle-and-cross" and "layer-by-layer") were successfully developed to construct osteon-like structures with microchannel networks. Significantly, the "layer-by-layer" approach employing the GelMA hydrogel with a higher biocompatibility was more favorable for building biomimetic osteon.
ISSN:	1364-548X
DOI:	10.1039/c2cc16744a