Amides from the stem bark of Fagara macrophylla

• Published in: Planta medica Vol. 75; no. 5; p. 517
• Main Authors: Wansi, Jean Duplex, Nwozo, Sarah Onyenibe, Mbaze, Luc Meva'a, Devkota, Krishna Prasad, Donkwe Moladje, Suzye Mireille, Fomum, Zacharias Tanee, Sewald, Norbert
• Format: Journal Article
• Language: English
• Published: Germany 01-04-2009
• Subjects: Adenocarcinoma - drug therapy; Alkaloids - chemistry; Alkaloids - isolation & purification; Alkaloids - pharmacology; Amides - chemistry; Amides - isolation & purification; Amides - pharmacology; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Cell Line, Tumor; Humans; Lung Neoplasms - drug therapy; Molecular Structure; Plant Bark; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Plant Stems; Rutaceae - chemistry
• ISSN: 1439-0221
• DOI: 10.1055/s-0029-1185327

Five new amide alkaloids, N-(4-hydroxyphenethyl)octacosanamide (1), N-(4-hydroxyphenethyl)hexacosanamide (2), N-(4-hydroxyphenethyl)decanamide (3), N-vanilloyltyramine (4), and N-[O-docosanoylvanilloyl]tyramine (5), were isolated from Fagara macrophylla, together with 15 known compounds. Their structures were established by using spectroscopic techniques, chemical reactions, and comparison with previously known analogues. A cytotoxicity assay was performed with the isolates, in which compounds 4, 8, and 9 were found to possess moderate to weak activity, with IC(50) values of 30.5, 11.5, and 13.5 microg/mL, respectively.